Pathogen Spectrum of Coronavirus Disease-2019(COVID-19)Associated Fungal Infection Patients of a Class A Tertiary Hospital
Objective To understand the spectrum of fungi of COVID-19 complicated with fungal infection patients in a third class A hospital from 10th December 2022 to 20th June 2023,providing pathogenic basis for COVID-19-associated fungal infections.Methods Retrospective analysis of the pathogen spectrum of COVID-19 is complicated by fungal infection patients,including the distribution of pathogens and sources of specimens and the correlation of fungi isolates with gender and age.All COVID-19 patients included in this study meet the confirmed diagnosis or clinical diagnosis criteria of invasive fungal infection.Identification of fungi uses the matrix-assisted laser desorption ionization time-of-flight Mass Spectrometry(MALDI-TOF-MS).For filamentous fungi were identified according to their colony and macroscopic characteristics and MALDI-TOF-MS.Results A total of 116 fungi were found in the 102 COVID-19 patients that were complicated by fungal infection between December 10,2022,and June 20,2023.The positive rates and strain numbers for Aspergillus,Candida,Rhizopus,and other classes were 57(49.41％),49(42.24％),4(3.45％),and 6(5.17％)respectively.14 patients were detected with two fungi.The detection of fungi in different age groups has statistical significance(P＜0.001).There is statistical significance in the identification of Aspergillus and Aspergillus fumigatus indifferent gender groups(P=0.005 and P=0.008,respectively).The detection of Candida,Aspergillus,Candida albicans,Aspergillus flavus and Aspergillus fumigatusin different age groups has statistical significance(P＜0.001,P＜0.001,P=0.006,P＜0.001 and P=0.009 respectively).The age group 80～90 years old had the second-highest constituent ratio(21.55％),after the 60～79 age group(62.93％).Conclusion Spectrum of fungi in COVID-19 patients were mainly candida and Aspergillus with Candida albicans and Aspergillus flavus being the most common,rare and important clinical fungi that should be paid attention to COVID-19 patients aged 60 years or above are susceptible to occur fungal co-infections.
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