Evaluation of the Effect of Clinical Pharmacists Intervention on the Prophylactic Use of Antibiotics During the Perioperative Period of Hemorrhoidectomy in Anorectal Department
Objective To evaluate the effect of special prescription comment mode intervention by clinical pharmacists on the prophylactic use of antibiotics during the perioperative period of hemorrhoidectomy in the anorectal department.Methods Using the most recent recommendations and expert consensus at home and abroad,construct comment criteria for prophylactic use of antibiotics during the perioperative period of hemorrhoidectomy,as well as a particular prescription comment mode.According to the inclusion and exclusion criteria,174 patients with hemorrhoidectomy admitted to the anorectal department from January to June 2022 were selected as the control group,and 150 patients with hemorrhoidectomy who underwent intervention by clinical pharmacists from January to June 2023 were selected as the intervention group.Comparison of prophylactic use of antibiotics during the perioperative period and hospitalization related indicators between two groups of patients.Results There was no statistically significant difference in general clinical data between the two groups of patients after comparison(P＞0.05).After the intervention of clinical pharmacists,the unreasonable rate of prophylactic use of antibiotics during the perioperative period of hemorrhoidectomy in the anorectal department significantly decreased.When compared to the control group,the intervention group exhibited significantly lower unreasonable rate in terms of drug selection,time,frequency,single dosage,duration,and combination use of medications(P＜0.05).The average hospitalization time,the average duration of antibiotics use,the average hospitalization cost,the average drug cost and the average antibiotics cost were all reduced to varying degrees(P＜0.05).In order to avoid infection during the perioperative phase,it is prefer to utilize second-generation cephalosporins in conjunction with second-or third-generation nitroimidazoles prior to intervention.After intervention,the usage rates of first-generation cephalosporins and first-generation nitroimidazoles significantly increased during the perioperative period,and the combination use of drugs was mainly cefazolin combined with metronidazole.Moreover,the antibiotics use density in the anorectal department was within the prescribed range every month,and the difference was statistically significant compared with before intervention(P＜0.05).Conclusions The intervention of clinical pharmacists significantly improved the rationality of the prophylactic use of antibiotics during the perioperative period of hemorrhoidectomy in the anorectal department,and effectively reduced the hospitalization cost of patients.
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