Structural Optimization and Innovative Design Methods of Antifungal Peptides
The overuse of a limited range of antifungal antibiotics has led to the rise of drug-resistant pathogens,underscoring the urgent need for new therapeutic alternatives to traditional antibiotics.In this regard,antifungal peptides hold significant promise for clinical applications due to their diverse mechanisms of action and reduced likelihood of inducing drug resistance in fungi.However,issues with low stability,high toxicity,and protracted research and development cycles prevent natural antifungal peptides from being widely used in design.Consequently,the design and synthesis of antifungal peptides have become a focal point of recent research efforts.This article provides a comprehensive review of the characteristics,origins,and mechanisms of action of antimicrobial peptides,while also discussing current research developments.Additionally,it highlights various strategies for the development of antifungal peptides,including rational design,combinatorial chemistry,and computer-aided design,with the aim of offering valuable insights for advancing research in this field.
antifungal peptidesmechanism of actionstructural modificationantibiotic resistancepeptide design
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