Recent Developments in the Study of Novel Azole-Based Hybrid Antifungal Agents
Fungal infections,particularly invasive fungal infections(IFI),pose a significant threat to global health,resulting in over 1.5 million deaths annually.This alarming statistic underscores the urgent need to develop new antifungal drugs.In clinical practice,azole antifungals are the most often used class of antifungal medicines and are essential for treating fungal infections.However,the effectiveness of traditional azole drugs is often limited by toxic side effects and the emergence of long-term drug resistance.Hybrid drugs have emerged as a highly promising strategy for developing new antifungal agents.By integrating advantageous structural elements from different drugs,it is possible to design novel antifungal compounds with enhanced activity.This review focuses on recent advances in hybrid antifungal drugs based on azole structures.These hybrids have shown great promise in terms of reduced toxicity,action against drug-resistant fungus,and antifungal efficacy,providing important information for creating next-generation antifungal treatments.
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