Distribution Characteristics and Drug Resistance Analysis of Carbapenem-Resistant Organisms in the ICU of a Hospital from 2020 to 2022
Objective To analyze the distribution characteristics,drug resistance and antibiotics use the density of carbapenem(AUD)of carbapenem-resistant organisms(CRO)in the intensive care unit(ICU),so as to provide the basis for rational drug use and control of bacterial resistance in ICU.Methods CRO strains isolated from the ICU of Pizhou People's Hospital Affiliated with Xuzhou Medical University from January 2020 to December 2022 were collected,and statistical analysis was performed by using Whonet 5.6 and SPSS 27.0 software.Results 30 strains(11.58％)of carbapenem-resistant Klebsiella pneumoniae(CRKP),10 strains(3.85％)of carbapenem-resistant Escherichia coli(CREC),39 strains(15.06％)of carbapenem-resistant Pseudomonas aeruginosa(CRPA),and 163 strains(62.93％)of carbapenem-resistant Acinetobacter baumannii(CRAB)were among the 260 CRO strains that were gathered.During the 3 years,the CRO detection rate increased from 11.68％to 22.69％,and the average detection rates of CRAB,CRPA,CRKP and CREC were 63.67％,13.40％,4.75％and 3.95％,respectively.The main source of samples was sputum(78.08％),followed by alveolar lavage fluid(6.54％),blood(3.85％)and so on.The total detection rate of CRO was highly positively correlated with the use intensity of carbapenems(r=1.00,P＜0.001).The four major CRO were generally resistant to common antibiotics and only sensitive to a small number of antibiotics.Among them,CRAB had a low resistance rate to tigecycline,doxycycline,minocycline and colistin,ranging from 0.61％to 35.58％;no tigecycline-resistant strains were detected in CRKP and CREC;CRPA was relatively less resistant to the other three CROs,and highly sensitive to colistin and amikacin.Conclusion In summary Since the CRO strains seen in the ICU have significant drug resistance,it is important to improve nosocomial infection prevention and control as well as antimicrobial management in order to lower the growth of drug-resistant organisms and stop their spread.
intensive care unitcarbapenem-resistant organismdrug resistancerational drug use
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