Clinical Distribution and Drug Resistance of the Four Gram-negative bacteria in a First-Class Hospital from 2017 to 2023
Objective To analyze the clinical distribution and drug resistance of the four main clinical Gram-negative in Dalian Friendship Hospital in recent 7 years,and to help the rational use of antibiotics in the treatment of Gram-negative infections.Methods A total of 6900 strains of samples from patients infected with four major gram-negative bacteria in our hospital from January 2017 to December 2023 were retrospectively counted.WHONET 5.6 software was used for analysis.Results The four predominant gram-negative bacteria were Acinetobacter baumannii(ABA)(1186 strains,10.0％),Pseudomonas aeruginosa(PAE)(1483 strains,12.5％),Escherichia coli(ECO)(2105 strains,17.7％),and Klebsiella pneumoniae(KPN)(2126 strains,17.9％).The main sources were sputum(2879 strains,41.7％)and urine(2010 strains,29.1％),and the detection rate in sterile body fluids was low.The most widely distributed departments were the intensive care unit(1498 strains,21.7％)and urology(1074 strains,15.6％).The highest percentage of ampicillin resistance was recorded by ECO in 2021(85.9％),whereas the highest rate of cefazolin resistance was recorded by KPN in 2017.Over the past 7 years,the antimicrobial resistance rate monitored by PAE was relatively low.The antimicrobial resistance rate monitored by ABA is relatively high.Conclusion It is necessary to strengthen the monitoring and management of clinical negative bacteria,especially for multi-drug resistant bacteria,which can guide the rational use of antibiotics.
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