Study for the Electrocardiographic Signal of Brugada Syndrome Patients Using Cellular Automaton
The relationship between the symptoms of Brugada Syndrome(BrS)patients and their abnormal conduction velocity(CV)restitution and abnormal action potential duration(APD)restitution are investigated using cellular automaton in this paper.Firstly,based on the characteristics of the electrocardiogram signals of BrS patients,the cellular automaton model is dimensionalized,and CV recovery and APD recovery are considered in the model.The behavior of the spiral wave of electrocardiographic signal related to the tachycardia is studied by using this model.The results indicate that only when CV recovery occurs,tachycardia will be maintained and will not worsen;Under the combined influence of CV recovery and memoryless APD recovery,tachycardia may disappear or transform into ventricular fibrillation,with a probability of 54％,significantly higher than clinical data;Under the combined influence of CV recovery and memory based APD recovery,tachycardia may disappear,maintain,or transform into ventricular fibrillation,with a conversion rate of 35％to ventricular fibrillation,which is consistent with clinical data.Tracking and observing the conduction of electrocardiogram signals near the wave head,it is found that the development of symptoms in BrS patients is related to the electrical signal conduction block caused by CV or APD recovery.The more severe the conduction block,the more likely BrS patients are to develop from tachycardia to ventricular fibrillation.Memory based APD recovery can reduce the incidence of ventricular fibrillation due to its memory effect,which can reduce the oscillation amplitude of APD.
万方数据
维普
