Objective:To explore the relationship and predictive efficacy of serum heat shock protein 70(HSP70),protein kinase D1(PKD1),chitinase protein 40(YKL-40)with lymph node metastasis in postmeno-pausal early endometrial cancer.Methods:A total of 126 patients with postmenopausal early endometrial cancer admitted to No.980 Hospital of PLA Joint Logistics Support Force from March 2021 to March 2023 were select-ed as the study group and divided into lymph node metastasis group(n=22)and non-lymph node metastasis group(n=104)according to the postoperative pathological diagnosis.Another 114 healthy individuals were selected as the control group.The serum levels of HSP70,PKD1 and YKL-40 in each group were compared.Multivariate lo-gistic regression analysis was used to analyze the factors affecting lymph node metastasis of patients.The receiv-er operating characteristic(ROC)curve was used to analyze the predictive value of serum HSP70,PKD1 and YKL-40 levels for lymph node metastasis of patients.Results:The serum levels of HSP70,PKD1 and YKL-40 in the study group were higher than those in the control group(P＜0.05).The proportion of low differentiation,uterine myometrial infiltration≥50%,and serum levels of CA125,HE4,HSP70,PKD1,and YKL-40 in patients with lymph node metastasis were higher than those in patients without lymph node metastasis(P＜0.05).Multi-variate logistic regression analysis showed that serum HE4,HSP70,PKD1 and YKL-40 levels and uterine myo-metrial infiltration≥50%were all independent risk factors for lymph node metastasis in patients with postmeno-pausal early endometrial cancer(all P＜0.05).The optimal cutoff points for serum HSP70,PKD1,and YKL-40 levels predicting lymph node metastasis in postmenopausal early endometrial cancer patients were 90.82 μg/L,132.23 μg/L,and 75.32 μg/L,respectively.The sensitivity,specificity,and area under the ROC curve(AUC)of the combined prediction of the three factors were 81.82%,96.15%,and 0.940,respectively.Conclusion:The se-rum levels of HSP70,PKD1 and YKL-40 in patients with early endometrial cancer can be used as sensitive indi-cators to predict lymph node metastasis,and the combined prediction of the three has a higher prediction efficien-cy.
endometrial cancerlymph node metastasismenopauseheat shock protein 70protein kinase D1chitinase protein 40
万方数据
维普
