Hepatocellular carcinoma(HCC)is one of the most prevalent and deadliest cancers.Most of the tri-partite motif(TRIM)family proteins have E3 ubiquitin ligase activity and are involved in the regulation of vari-ous cellular biology processes,including gene expression,cell cycle progress,apoptosis,signal transduction,and carcinogenesis.More and more studies suggest that members of the TRIM family play an important role in pro-moting the proliferation,migration and invasion of HCC cells.This review aims to discuss the role of the TRIM family in HCC,providing a basis for identifying new diagnostic and therapeutic targets for HCC.
维普
万方数据