Risk factors and prediction model construction of poor prognosis in patients with traumatic craniocerebral injury treated with hyperbaric oxygen therapy
Risk factors and prediction model construction of poor prognosis in patients with traumatic craniocerebral injury treated with hyperbaric oxygen therapy
Objective:To explore the risk factors of poor prognosis in patients with traumatic craniocerebral inju-ry treated with hyperbaric oxygen therapy and construct a prediction model,so as to provide a reference for fur-ther improving the prognosis of patients.Methods:A total of 182 patients with traumatic craniocerebral injury who received hyperbaric oxygen therapy in the Second Affiliated Hospital of Air Force Medical University from January 2021 to January 2023 were selected using the method of queue research.According to the Glasgow out-come scale(GOS)one month after treatment,they were divided into the poor prognosis group(n=119)and the good prognosis group(n=63).The clinical data of the two groups were compared.The logistic regression predic-tion model was constructed and the factors influencing the prognosis of hyperbaric oxygen therapy for traumatic craniocerebral injury were analyzed.The receiver operating characteristic(ROC)curve was used to analyze the value of multi-factor prediction of prognosis of hyperbaric oxygen therapy for traumatic craniocerebral injury.Re-sults:The incidence of subarachnoid hemorrhage and disappearance of annular cisterna in the poor prognosis group was higher than that in the good prognosis group,and the platelet count and plasma fibrinogen level were lower than those in the good prognosis group(all P＜0.05).The multivariate logistic regression model showed that subarachnoid hemorrhage and disappearance of annular cisterna were risk factors for the prognosis of pa-tients with traumatic craniocerebral injury treated with hyperbaric oxygen therapy,and the increase of platelet count and plasma fibrinogen level were protective factors(all P＜0.05).The areas under the ROC curve(AUC)of subarachnoid hemorrhage,disappearance of annular cisterna,platelet count and plasma fibrinogen for predict-ing the prognosis in patients with traumatic craniocerebral injury treated with hyperbaric oxygen therapy were 0.649,0.610,0.794 and 0.779,respectively(all P＜0.05),and the model was reliable and stable(AUC=0.894,P＜0.05).Conclusion:Subarachnoid hemorrhage,disappearance of annular cisterna,decreased platelet count and decreased plasma fibrinogen level are the influencing factors of poor prognosis in patients with traumatic brain injury treated with hyperbaric oxygen therapy.The prediction model based on the above risk factors has a high predictive value for poor prognosis of patients.
关键词
创伤性颅脑损伤/高压氧治疗/预后/影响因素/预测模型
Key words
traumatic craniocerebral injury/hyperbaric oxygen therapy/prognosis/influencing factors/predic-tion model
维普
万方数据