定量蛋白质组学技术在口腔鳞细胞癌中的应用进展
Progress in the application of quantitative proteomics technology in oral squamous cell carci-noma
麦晓群 1王涛 1温琦涛 1冼海瑜1
作者信息
- 1. 海南省人民医院口腔科,海口 570311;海南医学院附属海南医院,海口 571199
- 折叠
摘要
口腔鳞状细胞癌(OSCC)是最常见的头颈部恶性肿瘤之一,已经逐渐成为全球性的公共卫生问题,预防及早期诊断是减轻其负担的主要目标.定量蛋白质组学技术可用于定量细胞、组织或生物体的总体蛋白质含量,近年来被用于探索OSCC特异性的生物学标志物,研究其发病机制,寻找特异性治疗靶点等,为OSCC的早期诊断及治疗提供新思路.
Abstract
Oral squamous cell carcinoma(OSCC)is one of the most common head and neck malignancies and has become a global public health problem.Prevention and early diagnosis are the main goals to reduce its bur-den.Quantitative proteomics technology can be used to quantify the total protein content of cells,tissues or organ-isms.In recent years,it has been used to explore specific biological markers of OSCC,study its pathogenesis,and find specific therapeutic targets,providing new ideas for early diagnosis and treatment of OSCC.
关键词
定量蛋白质组学/口腔鳞状细胞癌/生物学标志物Key words
quantitative proteomics/oral squamous cell carcinoma/biological markers引用本文复制引用
基金项目
国家自然科学基金(81960199)
海南省重大科技计划()
海南省重点研发计划(ZDYF2021SHFZ114)
出版年
2024
国家科技期刊平台
NSTL
万方数据