The research progress of SERPINA3/Serpina3c mediated cell signaling axis in non-tumor dis-eases
SERPINA3/Serpina3c is a serine(or cysteine)peptidase inhibitor that inhibits cathepsin G and exerts anti-inflammatory effects.At present,most of the understanding of the functions of SERPINA3/Serpina3c comes from studies in the context of carcinogenesis.SERPINA3/Serpina3c is involved in various cellular biological pro-cesses such as gene expression,cell cycle progression,apoptosis,signal transduction,and carcinogenesis.In re-cent years,the study on SERPINA3/Serpina3c in non-tumor diseases is increasing.This article systematically ana-lyzes the research hotspots and trends of SERPINA3/Serpina3c,reviews its regulatory mechanisms on the cell sig-naling axis in non-tumor diseases,and provides some ideas for the molecular mechanism research of SERPINA3/Serpina3c in non-tumor diseases.
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