非肿瘤疾病中SERPINA3/Serpina3c介导的细胞信号轴的研究进展
The research progress of SERPINA3/Serpina3c mediated cell signaling axis in non-tumor dis-eases
覃梦岚 1朱素梅 1黎芳 2梁健钦 2丘琴1
作者信息
- 1. 广西中医药大学,南宁 530200
- 2. 广西中医药大学,南宁 530200;广西中医药大学中药制剂共性技术研发重点实验室,南宁 530200
- 折叠
摘要
SERPINA3/Serpina3c是一种丝氨酸(或半胱氨酸)肽酶抑制剂,可抑制组织蛋白酶G活性,发挥抗炎作用.目前对SER-PINA3/Serpina3c功能的了解大多数来自于癌变背景下的研究,认为它参与基因表达、细胞周期、凋亡、信号转导和癌变等多种细胞生物学过程.近年来,SERPINA3/Serpina3c在非肿瘤疾病中的研究也越来越多.本文系统分析了SERPINA3/Serpina3c的研究热点和趋势,综述了SERPINA3/Serpina3c在非肿瘤疾病对细胞信号轴的调控机制,为SERPINA3/Serpina3c在非肿瘤疾病中的分子机制研究提供思路.
Abstract
SERPINA3/Serpina3c is a serine(or cysteine)peptidase inhibitor that inhibits cathepsin G and exerts anti-inflammatory effects.At present,most of the understanding of the functions of SERPINA3/Serpina3c comes from studies in the context of carcinogenesis.SERPINA3/Serpina3c is involved in various cellular biological pro-cesses such as gene expression,cell cycle progression,apoptosis,signal transduction,and carcinogenesis.In re-cent years,the study on SERPINA3/Serpina3c in non-tumor diseases is increasing.This article systematically ana-lyzes the research hotspots and trends of SERPINA3/Serpina3c,reviews its regulatory mechanisms on the cell sig-naling axis in non-tumor diseases,and provides some ideas for the molecular mechanism research of SERPINA3/Serpina3c in non-tumor diseases.
关键词
SERPINA3/Serpina3c/信号通路/CiteSpace/文献计量分析Key words
SERPINA3/Serpina3c/signal pathway/CiteSpace/bibliometric analysis引用本文复制引用
基金项目
国家自然科学基金(81960872)
广西自然科学基金(2020GXNSFAA238035)
出版年
2024
国家科技期刊平台
NSTL
万方数据