Human immunodeficiency virus type 1(HIV-1)forms latent infection in cells,and the mechanism of latent HIV-1 infection remains unclear.As a result,current anti-retroviral therapies are unable to completely eradi-cate HIV-1 in infected individuals.Necroptosis,as a regulated form of cell death,can occur in several types of HIV-1-infected immune cells.At the same time,HIV can escape from cell death by inhibiting intracellular necrop-tosis-associated signaling pathways,which is conducive to the formation of HIV latent reservoir.In addition,necroptosis occurs mainly in HIV-1-infected cells and does not cause damage to nearby uninfected cells,which may be a potential target for targeted clearance of HIV latent reservoirs.This paper reviews the occurrence of necroptosis in HIV-1-infected cells and the related mechanisms,with a view of providing a reference for subse-quent studies on the mechanisms related to HIV-1 latent infection.
human immunodeficiency virus type 1latent infectionnecroptosiscell death
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