Objective:To analyze the differences of intestinal flora between newly diagnosed hypertension pa-tients and healthy individuals of Han nationality living in Yunnan Plateau based on 16S rDNA sequencing tech-nology.Methods:In the Han population of Yongsheng County,Lijiang City,Yunnan Province,23 Han patients newly diagnosed with hypertension(Group H),13 patients in the hypertension medication group(Group HM),and 26 healthy participants in Group C were selected based on the baseline survey data of the Chinese Multi-eth-nic Cohort(CMEC).Blood and fecal samples from the three study groups were collected for blood biochemical index detection and 16S rDNA sequencing technology analysis.Results:The α-diversity results showed that in-testinal flora richness in group H was decreased compared with group C(P=0.037).The β-diversity results re-vealed statistically significant differences among the three groups(R2=0.047,P=0.043),with the most significant difference between group HM and group C(R2=0.0552,P=0.005).At the genus level,compared with group C,the abundance of 7 bacterial genus was significantly decreased in group H,including Bifidobacterium,Collinsel-la,and Turicibacter,while the abundance of Enterococcus was significantly increased(all P＜0.05).Spearman correlation analyses between group H and group C showd that Bifidobacterium and Collinsella were negatively correlated with systolic blood pressure(SBP)and diastolic blood pressure(DBP)(P＜0.05).Receiver operating characteristics(ROC)curve analysis showed that the area under the curve(AUC)of Bifidobacterium and Collin-sella as microbial markers of hypertension was 0.78.Conclusion:The occurrence and development of hyperten-sion in Han people residing in the Yunnan Plateau are correlated with intestinal flora disorders,which is character-ized by a decrease in beneficial bacteria and an increase in harmful bacteria.Bifidobacterium and Collinsella may be used as microbial markers for hypertension in the plateau population,and supplementation of beneficial bacte-ria and adjustment of dietary structure can prevent and improve hypertension.
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