Recurrent spontaneous abortion(RSA)is a pregnancy complication with a complex etiology that seri-ously affects the physical and mental health of women of reproductive age.Although RSA is commonly thought to be caused by an imbalance in maternal-fetal immune tolerance,its specific immune mechanisms are not yet ful-ly understood.Recent studies have found that an imbalance in the immune microenvironment at the maternal-fe-tal interface,particularly abnormalities in the function and number of T lymphocytes and their related subsets,are closely related to the occurrence of RSA.This paper aims to review the latest research progress on T lymphocyte changes in RSA,exploring the potential connections between immune cell imbalance in the maternal-fetal inter-face immune microenvironment and RSA,so as to provide references for basic research and clinical treatment strategies.
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