Advancements in the epidemiology of nasopharyngeal carcinoma
Nasopharyngeal carcinoma(NPC)exhibits a remarkable geographical distribution,and its etiology has garnered significant attention,encompassing genetic,Epstein-Barr virus(EBV),and environmental factors.With the deepening of research,the epidemiological characteristics of NPC etiology have been gradually refined.This article focuses on the findings from one case-control study,the NPC genes,environment and Epstein Barr vi-rus(NPCGEE)project,conducted in Guangdong and Guangxi provinces,to summarize the latest advancements in the epidemiology of NPC etiology.Genetic factors play a crucial role in the etiology of NPC.Early EBV infec-tion may have a causal relationship with the development of NPC,and the high-risk subtypes of EBV may inter-act with host genes to jointly promote NPC progression.The NPCGEE project provides new insights into the epi-demiology of NPC,particularly in terms of environmental etiology:a diminished role of Chinese-style salt-preserved fish,modest positive associations with passive smoking and indoor air pollution,unclear associations with occupational exposure to formaldehyde and inhaled dust,and potential effects of oral health and the oral mi-crobiome on NPC.The etiological characteristics of NPC evolve with more rigorous research designs and envi-ronmental changes.To gain a deeper understanding of the interplay between NPC genetic factors,EBV and envi-ronment,large-scale pooled studies must accumulate sufficient cases with detailed exposure data.
万方数据
维普
