Research progress on the pathogenesis of primary membranous nephropathy
This article reviews the pathogenesis of primary membranous nephropathy(PMN)in recent years,en-compassing the latest findings of genetic,antigenic,environmental factors,and intestinal flora,etc.,so as to pro-vide a reference for further comprehension of the pathophysiological process and potential therapeutic targets as-sociated with PMN.In terms of genetic factors,the study identifies gene loci associated with the risk and progno-sis of PMN,such as phospholipase A2 receptor(PLA2R)and human leukocyte antigen(HLA).Regarding PMN antigens,this paper elaborates on PLA2R,thrombospondin type 1 domain-containing 7A(THSD7A),neutral en-dopeptidase(NEP),PMN neoantigen,and exogenous antigens in the diagnosis and treatment for membranous ne-phropathy.In addition,environmental factors such as air pollution,exposure to heavy metals and organic pollut-ants,and changes in gut microbiota may also be closely related to the incidence of PMN.The findings from this study offer innovative insights for the diagnosis and treatment of PMN.
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