SET::NUP214 fusion gene-positive acute leukemia in three patients:a literature review
Objective:To enhance the understanding of SET::NUP214 fusion gene-positive acute leukemia.Methods:A retrospective analysis was conducted on the clinical data of three patients with SET::NUP214 fusion gene-positive acute leukemia admitted to the First Affiliated Hospital of Guangxi Medical University from July 2018 to November 2019,and a review was carried out in combination with relevant literature.Results:Among the three patients with SET::NUP214 fusion gene-positive acute leukemia,one was diagnosed with acute T-lymphoblastic leukemia(T-ALL),one with acute myeloid leukemia(AML),and one with acute lymphoblastic leukemia L2(ALL-L2).Two patients had positive BCR::ABL fluorescence in situ hybridization(FISH)test re-sults at the time of diagnosis in the First Affiliated Hospital of Guangxi Medical University.The conventional treatment for ALL was ineffective.Both of the two ALL patients relapsed within 1 year.One AML patient achieved complete remission after chemotherapy and then underwent allogeneic transplantation,but relapsed ten months after transplantation.Conclusion:SET::NUP214 fusion gene-positive acute leukemia is rare,mainly seen in T-ALL,and the chromosomes can be normal.BCR::ABL FISH is conducive to early diagnosis,and the confir-mation requires fusion gene detection.The hormonal chemotherapy regimen for ALL is ineffective,with a short survival period and poor prognosis.Allogeneic transplantation may improve the prognosis of such patients.
万方数据
维普
