Research of the novel drug for photoactivated pyroptosis of bladder cancer
In this paper,a nanomaterial named ICG/RG108@BSA was designed to encapsulate indocyanine green(ICG)and RG108 using bovine serum protein(BSA).Indocyanine green activated protein Caspase-3 under near infrared laser induction and RG108 up-regulated the expression of GSDME by inhibiting DNA methylation,thus enhancing the pyroptosis of bladder cancer cells caused by Caspase-3 cleavage.ICG/RG108@BSA had excellent biocompatibility,which was effectively phagocytosed by bladder cancer cells.ICG/RG108@BSA produced significant killing effect on bladder cancer cells when activated by 755 nm laser,in which the survival rate of Mb49 was only 6.9%and the survival rate of T24 cells was only 10.7%.The 755 nm laser-excited ICG/RG108@BSA nanomaterial also successfully induced bladder cancer cell pyroptosis,providing a favorable therapeutic condition for tumor immunotherapy of bladder cancer.
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