摘要
目的 分析腹腔镜胃袖状切除术(LSG)治疗肥胖症的效果及对血清瘦素、脂联素水平的影响.方法 纳入50例行LSG治疗的肥胖症患者,统计患者的手术情况(手术时间、术中出血量、术后肛门排气时间、术后住院时间).术后随访6个月,比较患者术前和术后1个月、3个月、6个月的血清瘦素、脂联素水平及减重指标[体重、体质指数、多余体重减少百分比(EWL％)、腰围].统计患者术后6个月内不良反应的发生情况及合并症的改善情况.结果 50例患者均顺利完成手术,手术时间为70～160(118.6±20.4)min,术中出血量为24～75(48.3±18.7)mL,术后肛门排气时间为2～4(2.3±0.5)d,术后住院天数为4～10(8.2±2.4)d.患者的血清瘦素、脂联素水平及体重、体质指数、EWL％、腰围均有随时间变化的趋势(P＜0.05),其中,术后1个月、3个月、6个月,患者血清瘦素水平、体重、体质指数、腰围低于术前,血清脂联素水平高于术前,术后EWL％呈逐渐升高的趋势(P＜0.05).术后6个月,仅有1例患者出现肺部感染,患者的合并疾病均得到明显改善.结论 LSG治疗肥胖症的效果显著,可明显改善患者的血清瘦素和脂联素水平,还可以改善肥胖症的合并疾病,临床效果较好.
Abstract
Objective To analyze the effect of laparoscopic sleeve gastrectomy(LSG)for the treatment of obesity and its influence on serum leptin and adiponectin levels.Methods A total of 50 patients with obesity undergoing LSG for treatment were enrolled.Surgical status(operation duration,intraoperating bleeding volume,postoperative and exhaust time,and postoperative length of hospital stay)was analyzed.Patients were followed up for 6 months after operation,serum leptin and adiponectin levels,as well as weight loss indices(weight,body mass index,percentage of excess weight loss[EWL％],wast circumference)in patients were compared between before operation and 1 month,3 months,and 6 months after operation.The occurrence of adverse reactions and improvement of comorbidity within 6 months after operation were analyzed in patients.Results Operation was successfully completed in all 50 patients,and the operation duration was 70-160(118.6±20.4)minutes,intraoperative bleeding volume was 24-75(48.3±18.7)mL,postoperative anal exhaust time was 2-4(2.3±0.5)days,and postoperative length of hospital stay was 4-10(8.2±2.4)days.There was a tendency of patients'serum leptin and adiponectin levels,and weight,body mass index,EWL％,waist circumference over time(P＜0.05),therein serum leptin level,weight,body mass index,waist circumference of patients after 1,3,and 6 months of operation were lower than those before operation,whereas serum adiponectin level was higher than that before operation,and EWL％exhibited an increasing trend after 1,3,and 6 months after operation(P＜0.05).After 6 months of operation,only 1 patient suffered from pulmonary infection,and patients'concomitant diseases were all ameliorated.Conclusion LSG for treating obesity exerts a significant effect,which can prominently ameliorate patients'serum leptin and adiponectin levels,and improve concomitant diseases of obesity,exerting relatively favorable clinical effects.
维普
万方数据