Expression of serum circMTO1 in patients with hepatitis B associated cirrhosis and its correlation with degree of liver fibrosis and prognosis
Objective To analyze the expression of serum circular RNA mitochondrial tRNA translation optimization 1(circMTO1)in patients with hepatitis B associated cirrhosis and its relation with the degree of liver fibrosis and prognosis.Methods A total of 115 patients with hepatitis B associated cirrhosis(the hepatitis B cirrhosis group)and 120 patients with chronic hepatitis B(the chronic hepatitis B group)were enrolled as the research subjects.Patients in the hepatitis B cirrhosis group were assigned to favorable prognosis group(n=84)or adverse prognosis group(n=31)according to short-term prognosis after treatment.Serum circMTO1 expression was compared between the hepatitis B cirrhosis group and the chronic hepatitis B group,and between the favorable prognosis group and the adverse prognosis group.The correlation of serum circMTO1 expression with classification of liver fibrosis was analyzed in the hepatitis B cirrhosis group.The receiver operating characteristic curve was used to analyze the predictive value of serum circMTO1 expression on adverse prognosis in patients of the hepatitis B cirrhosis group.Results Patients in the hepatitis B cirrhosis group obtained a lower serum circMTO1 expression as compared with the chronic hepatitis B group,and serum circMTO1 expression was lower in the adverse prognosis group than in the favorable prognosis group(P＜0.05).Serum circMTO1 expression negatively correlated with classification of liver fibrosis in patients of the hepatitis B cirrhosis group(P＜0.05).Area under the curve of serum circMTO1 expression for predicting adverse prognosis in patients of the hepatitis B cirrhosis group was 0.747,the sensitivity was 77.40％,the specificity was 77.40％,and the optimal cut-off value was 0.332.Conclusion Compared with chronic hepatitis B patients without suffering from cirrhosis,patients with hepatitis B associated cirrhosis obtain a decreased serum circMTO1 expression,and it is related to the degree of liver fibrosis.Prognosis of patients with hepatitis B associated cirrhosis can be evaluated by circMTO1,which can be regarded as a molecular marker.
万方数据
维普
