Evaluation value of systemic immune-inflammation index,SYNTAX score and lipoprotein a level on the occurrence of in-stent restenosis in elderly patients with coronary artery disease after PCI
Objective To investigate the evaluation value of systemic immune-inflammation index(SII),SYNTAX score,and lipoprotein a level on the occurrence of in-stent restenosis(ISR)in elderly patients with coronary heart disease after percutaneous coronary intervention(PCI).Methods A retrospective analysis was conducted on the clinical data of 504 elderly patients with coronary heart disease who underwent PCI and subsequent coronary angiography(CAG).According to whether ISR one year after PCI occurred or not,patients were divided into non-ISR group(n=410)or ISR group(n=94).The general data,laboratory indices,SII,and SYNTAX score were compared between patients of the two groups.The multivariate Logistic regression model was used to analyze the influencing factors for the occurrence of ISR after PCI in elderly patients with coronary heart disease.The receiver operating characteristic(ROC)curve was drawn to analyze the evaluation value of SII,SYNTAX score,and lipoprotein a level on the occurrence of ISR in elderly patients with coronary heart disease after PCI.Results A total of 94 patients suffered from ISR,with the incidence rate in 18.7％.Compared with the non-ISR group,the ISR group exhibited a higher pulse pressure difference,a higher proportion of patients with a history of chronic renal insufficiency,and higher SII,SYNTAX score,white blood cell counts,as well as higher levels of total cholesterol,lipoprotein a,HbAlc,fibrinogen,and troponin I(P＜0.05).The results of multivariate Logistic regression analysis revealed that high SII,high SYNTAX score,and high lipoprotein a level were the independent risk factors for the occurrence of ISR in elderly patients with coronary heart disease after PCI(P＜0.05).The results of ROC curve analysis indicated that areas under the curve of SII,SYNTAX score,and lipoprotein a level for alone and jointly evaluating the occurrence of ISR in elderly patients with coronary heart disease after PCI were 0.725,0.753,0.701,and 0.829,respectively,and area under the curve of the combination of the three was larger than that of single index(P＜0.05).Conclusion High SII,high SYNTAX score,and high lipoprotein a level are the independent risk factors for the occurrence of ISR in elderly patients with coronary heart disease after PCI.SII,SYNTAX score,and lipoprotein a level exert evaluation efficiency on the occurrence of ISR in elderly patients with coronary heart disease after PCI to a certain extent,and their combination exhibits superior evaluation efficiency.
万方数据
维普
