Objective To investigate whether the interaction between serum vitamin D and serum uric acid has an effect on blood pressure.Methods A oross-sectional study was conducted with 7 951 subjects selected from the health management center of the Second Hospital of Dalian Medical University during January 1,2020 and Septem-ber 30,2022.The dose-response relationship between serum vitamin D,blood uric acid and blood pressure was ana-lyzed using restricted cubic spline.The relationship between each variable and elevated blood pressure was analyzed using multifactorial analysis in a generalized additive model and combined with a multiplicative-additive hierarchical interaction model to explore the effects of the interaction of serum vitamin D and blood uric acid on elevated blood pressure.Results The mean age of the study population was(42.6±11.2)years and the detection rate of hyper-tension was 12.14％(965/7 951).The risk of elevated blood pressure(high-normal blood pressure+hyperten-sion)decreased with increasing serum vitamin D concentration,but the risk of elevated blood pressure increased with increasing serum uric acid levels.Compared with those with adequate serum vitamin D and normal blood uric acid,the OR for the risk of high-normal blood pressure was 1.54(95％CI 1.22-1.94,P＜0.001)and the OR for the risk of hypertension was 3.17(95％CI 2.13-4.72,P＜0.001)for those with inadequate serum vitamin D and high blood uric acid.The risk of elevated blood pressure was highest when serum 25-hydroxyvitamin D was less than 25 nmol/L and blood uric acid was higher than 600 pmol/L.Conclusions The interaction between serum vitamin D and blood uric acid has an effect on elevated blood pressure.The risk of hypertension is maximized when serum vitamin D is insufficient and blood uric acid is high.
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