摘要
目的 探讨青年人群维持正常血尿酸的因素.方法 以2006-2016年度首次参加开滦研究时年龄＜30岁、血尿酸正常、完成至少两次体检且体检资料完整的职工为研究对象,最终纳入统计分析者共13 212例.以完成首次体检作为随访起点,最后一次体检为随访终点,以维持血尿酸正常为终点事件.采用Cox回归模型分析相关因素与维持青年人群正常血尿酸之间的关联.结果 纳入人群基线平均年龄为(25.7±2.6)岁.8 974名参与者(67.9％)在(7.2±3.8)年的随访中维持了正常血尿酸.多因素Cox回归分析结果显示,基线肾功能正常、进行体育锻炼、不饮酒、血压正常、血糖正常、血脂正常、体重指数正常、受过高等教育与维持正常血尿酸之间存在关联,其HR 值(95％CI)分别为 1.416(1.250～1.603)、1.289(1.209～1.375)、1.239(1.177～1.305)、1.181(1.091～1.279)、1.158(1.027～1.305)、1.132(1.070～1.197)、1.122(1.040～1.210)、1.114(1.065～1.167).结论 肾功能正常、进行体育锻炼、不饮酒、血压正常、血糖正常、血脂正常、体重指数正常、受过高等教育是开滦研究青年人群维持正常血尿酸的保护因素.
Abstract
Objective To explore the influencing factors of maintaining normal serum uric acid in young people.Methods Employees who were under 30 years old and had normal blood uric acid levels at the first physical exami-nation between 2006 and 2016,completed at least two physical examinations and had completed physical examination data were selected from Kailuan study,and finally 13 212 participants were included in the statistical analysis.The follow-up started from the first physical examination and ended at the last physical examination,with maintaining normal blood uric acid levels as the end point.Cox regression model was used to analyze the relationship between re-lated factors and maintaining normal serum uric acid in young people.Results The average baseline age of the in-cluded population was(25.7±2.6)years old.A total of 8 974 participants(67.9％)maintained normal serum uric acid during(7.2+3.8)years of follow-up.Cox regression analysis showed that there was a correlation between nor-mal renal function,physical exercise,non-drinking,normal blood pressure,normal blood glucose,normal blood lip-ids,normal body mass index,higher education and maintenance of normal serum uric acid,with hazard ratio(HR)values(95％CI)of 1.416(1.250-1.603),1.289(1.209-1.375),1.239(1.177-1.305),1.181(1.091-1.279),1.158(1.027-1.305),1.132(1.070-1.197),1.122(1.040-1.210),1.114(1.065-1.167).Conclusion Nor-mal renal function,physical exercise,non-drinking,normal blood pressure,normal blood glucose,normal blood lip-id,normal body mass index and higher education are the protective factors to maintain normal serum uric acid in young people from Kailuan study.
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