中老年原发性高血压患者血清甲状旁腺素、25-羟维生素D水平与左心室肥厚的相关性
Correlation between serum parathyroid hormone,25-hydroxyvitamin D levels and left ventricular hypertrophy in middle-aged and elderly patients with essential hypertension
易春秀 1赵雅静 1张雯 1张彩艳 1郭子宏1
作者信息
- 1. 云南省阜外心血管病医院心血管内科,云南 昆明 650032
- 折叠
摘要
目的 探讨中老年原发性高血压患者血清甲状旁腺素(PTH)、25-羟维生素D[25(OH)D]水平与左心室肥厚(LVH)指标的相关性.方法 随机收集2022年11月至2023年5月在云南省阜外心血管病医院心内科高血压病区住院的中老年原发性高血压患者204例,根据是否发生LVH分为LVH组(45例)、非LVH组(159例);采集患者的人口学资料、血红蛋白、尿酸、肌酐、血清钙离子、血清磷离子、动态血压及PTH、25(OH)D等指标.采用Pearson相关性分析方法分析原发性高血压患者PTH、25(OH)D与LVH的相关性;采用多元逐步线性回归分析方法分析原发性高血压患者血清PTH、25(OH)D对LVH的影响.结果 LVH组PTH高于非LVH组[(56.19±27.16)比(49.01±18.78)ng/L,t=-2.036,P=0.043],25(OH)D 低于非 LVH 组[(46.95±15.80)比(53.35±17.18)nmol/L,t=2.239,P=0.026].Pearson相关性分析显示,PTH与室间隔厚度(IVST)、左心室质量指数(LVMI)呈正相关(r=0.203,P=0.004;r=0.170,P=0.015).多元逐步线性回归分析显示,PTH是LVMI的影响因素(β=0.169,P=0.016).结论 原发性高血压患者PTH与LVMI呈正相关,PTH是LVH的影响因素.
Abstract
Objective To investigate the correlation between serum levels of parathyroid hormone(PTH),25-hydroxyvitamin D[25(OH)D]and left ventricular hypertrophy(LVH)in middle-aged and elderly patients with essential hypertension.Methods A total of 204 middle-aged and elderly patients with essential hypertension were randomly collected from the Hypertension Ward of the Cardiovascular Department,Fuwai Yunnan Hospital,Chinese Academy of Medical Sciences between November 2022 and May 2023.The patients were divided into LVH group(45 cases)and non-LVH group(159 cases).Demographic information,hemoglobin,uric acid,creatinine,serum calcium ions,serum phosphorus ions,ambulatory blood pressure monitoring and PTH,25(OH)D were collected.Pearson correlation analysis was used to analyze the correlation between PTH,25(OH)D and LVH in essential hy-pertension patients.Multivariate stepwise linear regression analysis was used to analyze the effect of serum PTH,25(OH)D on LVH in essential hypertensive patients.Results Compared with non-LVH group,PTH was higher[(56.19±27.16)vs(49.01±18.78)ng/L,t=-2.036,P=0.043],while 25(OH)D was lower[(46.95±15.80)vs(53.35±17.18)nmol/L,t=2.239,P=0.026]in the LVH group.Pearson correlation analysis showed that PTH was positively correlated with interventricular septal thickness(IVST)and left ventricular mass index(LVMI)(r=0.203,P=0.004;r=0.170,P=0.015).Multiple stepwise linear regression analysis showed that PTH(β=0.169,P=0.016)was an influence factor of LVMI.Conclusion PTH is positively associated with LVMI in essential hypertensive patients,and PTH is an influencing factor of LVH.
关键词
原发性高血压/甲状旁腺素/25-羟维生素D/左心室肥厚Key words
essential hypertension/parathyroid hormone/25-hydroxyvitamin D/left ventricular hypertrophy引用本文复制引用
出版年
2024
NETL
NSTL
万方数据