红背山麻杆(Alchornea trewioides )为山麻杆属植物,作为传统的中药被用来减轻疾病和身体不适,但它的药效物质基础尚未完全清楚。为了全面掌握红背山麻杆药效物质基础,采用80％丙酮对其新鲜叶进行提取,并利用 MCI gel CHP 20P、Sephadex LH-20等色谱柱进行分离共得到9个化合物。这些化合物的结构经氢谱与碳谱比较分析鉴定为鞣花酸(1)、3-O-甲基没食子酸(2)、decarboxyellagic acid(3)、1-O-没食子酰基-β-D-葡萄糖(4)、1,6-二-O-没食子酰基-β-D-葡萄糖(5)、柯里拉京(6)、叶下珠鞣质 D(7)、furosonin(8)、老鹳草素(9)。其中化合物2~9均为首次从该属植物中分离得到。
Chemical constituents from the leaves of Alchornea trewioides (4).Polyphenols
Alchornea trewioides ,as atraditional Chinese medicine,was used to alleviate illness and discomfort in Chi-na,but the material basis of pharmacodynamic was unknown.In order to research for the material basis of pharmaco-dynamic from A .trewioides leaves,the fresh leaves of A .trewioides were extracted with 80% aqueous acetone and assigned by petroleum ether and water.The petroleum ether and water extracts were subjected to the column chro-matography by MCI gel CHP 20P,Sephadex LH-20,and Toyopearl Butyl-650C,respectively,to yield nine poly-phenols.Their structures were identified by means of 1 H NMR,1 3 C NMR,DEPT,and comparison with literature as:ellagic acid(1),3-O-methylellagic acid(2),decarboxyellagic acid(3),1-O-galloyl-β-D-glucose(4),1,6-di-O-galloyl-β-D-glucose(5),corilagin(6),phyllanthusiin D(7),furosonin(8),and geraniin(9),respectively.Compounds 2-9 were obtained from A .trewioides for the first time.
Alchornea trewioideschemical constituentspolyphenolsellagic acidextraction and separation
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