Biological source elicitor mainly comes from pathogenic microorganisms,other microorganisms,and host plants or produced by the host-pathogen interaction.The elicitor produced by the pathogenic microorganisms or other microorganisms including the fungal of β-glucan,glycoprotein,lipid and other cell wall components.The elicitor produced by the host plants mainly oligosaccharide substance in the cell wall components,such as oligogalacturonide acid and xlylan fragment,and the elicitor produced by the interaction of host and pathogen mainly for the enzyme for the host,and pathogens in the process of cell components after modification.Mter through a series of signal transduction,host plant was induced to produce ethylene,plant protection,salicylic acid,jasmonic acid and pathogenesis related protein,which led to a variety of defensive reaction in plants,so as to control the development and spread of the disease.It is helpful to reduce the diseases and insect pests in the production of plants to achieve the purpose of production.In the past few years,many people were in the elicitor research in a wide range.The function of biological source elicitor in the biological control also increasingly brought to the attention of scholars.Currently,they still insist on their own studies,and towards to the deeper field,a lot of new scientists joined in this field.In this paper,research progress and application in agriculture were reviewed between the category of elicitor on biological,such as Harpin protein,Nep1-like protein,RXLR protein,Elicitins and so on,all these elicitors are employed directly or indirectly describe in this review.This review also highlights the integration of signaling pathways into or by transcription factors,as well as the linkage of the above signal components in elicitor signaling network through protein phosphorylation and dephosphorylation.Some perspectives on elicitor signal transduction are also presented.Cross talk between different functions is very common in different elicitors,which all act as a role of plant defense response.The mechanism of elicitors also mentioned in this review.And we have also proposed the use of biological protein elicitors for prevention and treatment of diseases in agricultural production in the future.