Optimization of Preparation Technology of Fumigation Shujin Decoction Based on Orthogonal Test Method
[Objective]To optimize the extraction process of fumigation Shujin decoction.[Methods]The soaking time,ethanol volume fraction and ethanol dosage as elevation factors,mesaconitine and hypaconitine as evaluation in-dexes,L9(34)orthogonal test design was used to optimize the extraction process according to the comprehensive score.[Results]The optimal extraction process of fumigation Shujin decoction is as follows:1 portion of crude powder of fresh Aconiti radix and fresh Aconiti kusnezoffii radix were weighed according to the prescription ratio of fumigation Shujin decoction,soaked in 2 times of 80% ethanol for 12 h,and then put into the percolation cylinder and added with 10 times of 80% ethanol for percolation.The percolation liquid was collected and the ethanol was recovered under reduced pressure until the liquid had no alcohol taste.Then the residue of fresh Aconiti radix and fresh Aconiti kusnezoffii radix were boiled and extracted twice with the eight herbs as Artemisiae argyi folium,Euonymi alati caulis,sappan lignum,Carthami flos,Zanthoxyli radix,Erythrinae cortex,Parthenocissus tricuspidate and Impatientis balsaminae caulis.The first time was 1.5 h,and the second time was 1 h.After filtration,the residue was discarded,the filtrate was concentrat-ed,cooled,and mixed with the percolation solution.The Camphor was ground into fine powder,dissolved with alcohol in a ratio of 1∶10 and added to the concentrated liquid,and the water was added to 1 000 ml.[Conclusion]The opti-mized process of fumigation Shujin decoction is stable and feasible,which can provide basis for further industrial pro-duction.
fumigation Shujin decoctionweighted scoreorthogonal test methodprocess optimization
万方数据
维普
