The Effects of Dexmedetomidine on Implicit and Explicit Memory in Patients with Combined Spinal-epidural Anesthesia under Different Cerebral State Index
[Objective]To investigate the effects of dexmedetomidine on implicit and explicit memory in patients with combined spinal-epidural anesthesia under different cerebral state index(CSI).[Methods]A total of 80 patients who planned to applied combined spinal-epidural anesthesia were randomly divided into D1 group(CSI>60～80)and D2 group(CSI 40～60)by random number table method,with 40 patients in each group.All the patients were applied combined spinal-epidural anesthesia,auditory stimulus were presented when the anesthesia took effect and met surgi-cal requirements.The first stimulus was presented when the patients were awake before pumping dexmedetomidine hy-drochloride.The second auditory stimulus was presented when reached to set CSI after pumping dexmedetomidine hy-drochloride.MAP、HR and SpO2 were recorded before pumping dexmedetomidine hydrochloride(T0),when CSI reach-es the set level after pumping(T1),and CSI recovered to 90(T2).6 hours after T2,memory test were conducted.[Re-sults]At T1,MAP and HR of both groups of patients were significantly lower compared to those at T0,with statistical sig-nificance(P<0.05).There was no significant difference in SpO2 among the same time points for the two groups(P>0.05).At T1,MAP and HR of D2 group were significantly lower than those of D1 group(P<0.05);there was no signifi-cant difference in SpO2 between these two groups(P>0.05).In D1 group,the difference between the implicit memory score[0.09(0.03,0.15)]and zero(score of no memory)was significant(P<0.05),while the difference between the explicit memory score[0.03(0.00,0.10)]and zero was not(P>0.05).In group D2,there was no statistical difference between the implicit memory score[0.02(-0.03,0.11)]and zero,so as the explicit memory score[0.01(-0.01,0.13)](P>0.05).[Conclusion]Dexmedetomidine can inhibit the formation of explicit memory in patient with combined spi-nal-epidural anesthesia under CSI>60～80,while can not inhibit the formation of implicit memory.It can inhibit the for-mation of both implicit and explicit memory in patients with combined spinal-epidural anesthesia under CSI 40～60.
dexmedetomidinecerebral state index(CSI)implicit memoryexplicit memoryprocess dissociation procedure
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