Effect Observation of Hexue Mingmu Tablet Combined with Aflibercept in the Treatment of Diabetic Macular Edema
[Objective]To observe the effect of Hexue Mingmu tablet combined with Aflibercept in the treatment of diabetic macular edema(type of yin deficiency with blood stasis).[Methods]Sixty three patients with diabetic macular edema(type of yin deficiency with blood stasis)were selected and randomly divided into the observation group with 32 cases and the control group with 31 cases.Both groups were given intravitreal injection of Aflibercept,0.05 ml per eye,once a month in 5 straight months.On this basis,the observation group was also given regular dose of Hexue Mingmu tablet orally.Then the clinical efficacy,the scoring of symptoms in TCM and physical sign,the best corrected visual acuity,the macular fovea retinal thickness,serum inflammatory factor level,D-dimer level before and after treatment,and the number of Aflibercept injection in 1-year follow-up in these two groups were compared.[Results]Due to the drop-out of 12 patients,27 in the observation group and 24 in the control group completed the observation.The clinical efficacy of the observation group was significantly better than that of the control group(P<0.05).Blurred vision,dark shadow,microhemangioma,fundus hemorrhage and exudation were improved in both groups(P<0.05).In the observa-tion group,excessive thirst,insomnia with restlessness and dizziness were significantly improved(P<0.05),but there was no significant improvement in control group(P>0.05).After treatment,all symptoms and signs scoring in the ob-servation group were better than those in the control group(P<0.05).The best corrected visual acuity was improved and the macular fovea retinal thickness was reduced after treatment in both groups compared to those before treatment,and these efficacy in the observation group was better than that of the control group(P<0.05).The levels of serum inflammatory factors and D-dimer in both groups were significantly decreased after treatment compared to those before treatment,and the levels in the observation group was lower than that of the control group(P<0.05).The number of Aflibercept injection in 1-year follow-up in the observation group was significantly less than that in the control group(P<0.05).[Conclusion]Hexue Mingmu tablet combined with Aflibercept in the treatment of diabetic macular edema(type of yin deficiency with blood stasis)can not only effectively improve clinical symptoms and sighs,improve vision,promote the regression of macular edema,improve blood hypercoagulability and inhibit serum inflammatory factors,but also reduce the num-ber of Aflibercept injection.
Hexue Mingmu tabletAfliberceptdiabetic macular edematype of yin deficiency with blood stasisclinical efficacy observation
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