摘要
[目的]探讨加用活血归元汤加味治疗慢性胃炎(chronic gastritis,CG)伴抑郁的临床效果.[方法]选取118例CG伴抑郁患者,按随机数字表法分为联合组、对照组各59例,对照组采用西医综合疗法,联合组在对照组基础上联合活血归元汤加味治疗,疗程为2个月.对比两组疗效、中医症状评分、简单自测抑郁量表(PHQ-9)评分、复发率以及血清炎症因子[单核细胞趋化蛋白-1(MCP-1)、白细胞介素(IL)-8、IL-32]水平.[结果]联合组总有效率为98.31%,对照组为86.44%,联合组疗效优于对照组(P<0.05);随访2个月联合组的复发率为1.69%,对照组为15.25%,差异有显著性意义(P<0.05).治疗2个月后联合组胃脘或胁肋胀痛、腹胀、食少纳呆、便溏不爽、情绪抑郁、急躁易怒等中医症状评分均低于对照组(P<0.05),联合组PHQ-9评分低于对照组(P<0.05);联合组MCP-1、IL-8、IL-32水平低于对照组(P<0.05).[结论]加用活血归元汤加味治疗CG伴抑郁患者,可有效改善临床症状,减轻机体炎症反应.
Abstract
[Objective]To investigate the clinical effectiveness of the combining use of modified Huoxue Guiyuan decoction in the treatment of chronic gastritis(CG)accompanied by depression.[Methods]By the random number ta-ble method,118 patients with CG and depression were randomly divided into a combined treatment group and a control group,with 59 patients in each.The control group received comprehensive western medicine therapy,while the com-bined treatment group received the treatment of the modified Huoxue Guiyuan decoction in addition to the same western medicine treatment in the control group.The course of treatment lasted for 2 months.Comparisons were made between the two groups in terms of efficacy,traditional Chinese medicine(TCM)symptom scores,patient health questionnaire-9(PHQ-9)scores,recurrence rates,and serum levels of inflammatory cytokines[monocyte chemoattractant protein-1(MCP-1),interleukin(IL)-8,and IL-32].[Results]The total effective rate was 98.31%in the combined treatment group and 86.44%in the control group,indicating that the combined treatment group had superior efficacy(P<0.05).After a 2-month follow-up,the recurrence rate in the combined treatment group was 1.69%,which was significantly lower than the 15.25%in the control group(P<0.05).After 2 months of treatment,the combined treatment group had lower TCM symptom scores for epigastric or hypochondriac distension and pain,abdominal distension,anorexia,loose and sticky stool,emotional depression,irritability,and other symptoms compared to the control group(P<0.05).Addi-tionally,the PHQ-9 scores in the combined treatment group were lower than those in the control group(P<0.05).The levels of MCP-1,IL-8,and IL-32 in the combined treatment group were also lower than those in the control group(P<0.05).[Conclusion]The combining use of modified Huoxue Guiyuan decoction can effectively improve the clinical symptoms and reduce inflammatory responses in the cases with CG accompanied by depression.
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