Clinical Effect of the Combining Use of Modified Huoxue Guiyuan Decoction on Chronic Gastritis with Depression
[Objective]To investigate the clinical effectiveness of the combining use of modified Huoxue Guiyuan decoction in the treatment of chronic gastritis(CG)accompanied by depression.[Methods]By the random number ta-ble method,118 patients with CG and depression were randomly divided into a combined treatment group and a control group,with 59 patients in each.The control group received comprehensive western medicine therapy,while the com-bined treatment group received the treatment of the modified Huoxue Guiyuan decoction in addition to the same western medicine treatment in the control group.The course of treatment lasted for 2 months.Comparisons were made between the two groups in terms of efficacy,traditional Chinese medicine(TCM)symptom scores,patient health questionnaire-9(PHQ-9)scores,recurrence rates,and serum levels of inflammatory cytokines[monocyte chemoattractant protein-1(MCP-1),interleukin(IL)-8,and IL-32].[Results]The total effective rate was 98.31%in the combined treatment group and 86.44%in the control group,indicating that the combined treatment group had superior efficacy(P<0.05).After a 2-month follow-up,the recurrence rate in the combined treatment group was 1.69%,which was significantly lower than the 15.25%in the control group(P<0.05).After 2 months of treatment,the combined treatment group had lower TCM symptom scores for epigastric or hypochondriac distension and pain,abdominal distension,anorexia,loose and sticky stool,emotional depression,irritability,and other symptoms compared to the control group(P<0.05).Addi-tionally,the PHQ-9 scores in the combined treatment group were lower than those in the control group(P<0.05).The levels of MCP-1,IL-8,and IL-32 in the combined treatment group were also lower than those in the control group(P<0.05).[Conclusion]The combining use of modified Huoxue Guiyuan decoction can effectively improve the clinical symptoms and reduce inflammatory responses in the cases with CG accompanied by depression.
NETL
NSTL
万方数据
