Clinical study on Small Bupleurum Decoction combined with repetitive transcranial magnetic stimulation and duloxetine hydrochloride in the treatment of female somatoform disorders
Clinical study on Small Bupleurum Decoction combined with repetitive transcranial magnetic stimulation and duloxetine hydrochloride in the treatment of female somatoform disorders
Objective:To observe the efficacy and safety of Small Bupleurum Decoction combined with repetitive transcranial magnetic stimulation and duloxetine hydrochloride in the treatment of female somatoform disorders.Meth-ods:A total of 90 female patients with somatoform disorders were randomly divided into three groups:control group No.1,control group No.2,observation group,with 30 cases in a group.The control group No.1 was treated with duloxetine hydrochloride capsules.The control group No.2 was treated with repetitive transcranial magnetic stimulation on the ba-sis of duloxetine hydrochloride capsules.The observation group was treated with Small Bupleurum Decoction on the ba-sis of the control group No.2.The three groups were treated continuously for 8 weeks.The changes of mental symptom self-rating scale(SCL-90)score,Hamilton depression scale(HAMD)score,Hamilton anxiety scale(HAMA)score,TCM syndrome score,serum 5-hydroxytryptamine(5-HT),norepinephrine(NE),estradiol(E2)and adverse events were observed in each group.Results:After 8 weeks of treatment,the scores of SCL-90,HAMD,HAMA and TCM syn-dromes in the observation group were lower than those in the control group No.1 and the control group No.2(P<0.05).After 8 weeks of treatment,the levels of serum 5-HT,NE and E2 in the three groups were higher than those before treat-ment and 4 weeks after treatment.The levels of 5-HT,NE and E2 in the control group 2 were higher than those in the control group No.1(P<0.05).The values of 5-HT,NE and E2 in the observation group were higher than those in the control group No.2(P<0.05).Conclusion:Small Bupleurum Decoction combined with repetitive transcranial magnetic stimulation and duloxetine hydrochloride can improve the somatic symptoms of female patients with somatoform disor-ders,and the curative effect is good.
关键词
躯体形式障碍/女性/小柴胡汤/重复经颅磁刺激/盐酸度洛西汀
Key words
Somatoform disorder/Femal/Small Bupleurum Decoction/Repetitive transcranial magnetic stimula-tion/Duloxetine hydrochloride
维普
万方数据