Clinical research on supplemented Guipi decoction combined with Deanxit in the treatment of ischemic post-stroke depression of deficiency of the heart and spleen type
Objective:To observe the therapeutic effect of the supplemented Guipi decoction combined with Deanx-it in the treatment of ischemic post-stroke depression(IPSD)of deficiency of the heart and spleen type.Methods:A to-tal of 80 patients with IPSD of deficiency of the heart and spleen type were randomly divided into two groups,with 40 cases in each group.The observation group received treatment with Deanxit,while the traditional Chinese medicine(TCM)group was treated with supplemented Guipi decoction on the basis of the control group.The course of treatment for both groups was four weeks.Evaluation of NIHSS scores,HAMD scores,SF-36 scores,5-hydroxytryptamine(5-HT)levels,homocysteine(Hcy)levels,clinical effects,and the incidence of adverse reactions was conducted in two groups before and after treatment.Results:After treatment,the HAMD scores,SF-36 scores,NIHSS scores,and levels of 5-HT and Hcy all showed improvement in both groups(P<0.05).Furthermore,the TCM group demonstrated a more significant improvement compared to the control group,with statistically significant differences(P<0.05).The total ef-fective rate in the TCM group was 95.00%,surpassing the 80.00%observed in the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions in the TCM group was 5.0%,lower than the 17.5%observed in the control group(P<0.05).Conclusion:The combination of supplemented Guipi decoction and Deanxit can improve the depressive symptoms in patients with IPSD of deficiency of the heart and spleen type,with a high level of safety.
Guipi decoctiondeficiency of the heart and spleen typestrokedepressionclinical observation
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