The application of HC-120 catalyst in a company's 2.20 Mt·a-1 hydrocracking unit was introduced.The results show that HC-120 catalyst has good activity,selectivity,high product quality and reasonable product distribution.Compared with the prolific diesel cracking catalyst HC-115 used in the previous cycle,the initial operating reaction temperature is relatively low,the hydrogen consumption is reduced,the heavy naphtha yield is increased by about 5.3 percentage points,the jet fuel yield is increased by 3.4 percentage points,and the diesel oil yield is reduced by 5.0 percentage points,which can effectively reduce the diesel fuel ratio.While the yield of heavy naphtha+jet coal is increased by 8.7percentage points,the hydrogen yield is still decreased,which greatly improves the hydrogen utilization efficiency.At the same time,due to the increase of catalyst activity,the energy consumption of the device is reduced,and the economic benefit of the device is improved.The catalyst has good popularization value.