Performance study on palladium-carbon catalyst for synthesis of pregnenolone acetate
Pregnenolone acetate is an important intermediate in the synthesis of progesterone drugs.The synthesis process is based on anhydrous ethanol as solvent,under the action of 5%Pd/C catalyst and H2,the carbon-carbon double bond(C—C)in the structure of dienolone acetate is hydrogenated to produce pregnenolone acetate.The results showed that the optimum conditions for the synthesis of pregnenolone acetate were as follows:the amount of catalyst was 0.4 g,the reaction temperature was 45℃,the reaction time was 120 min,and the reactor speed was greater than 500 r·min-1.The carrier was pretreated with 3%nitric acid,modified with 5%ammonium persulfate,and then modified with 2.5%magnesium chlo-ride to produce a catalyst with the best reaction performance.
fine chemical engineeringpregnenolone acetate16-dehydropregnenolone acetatepalladium-carbon catalyst
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