首页|基于GATE的碳离子放疗模体辐射场蒙特卡洛仿真研究

基于GATE的碳离子放疗模体辐射场蒙特卡洛仿真研究

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基于GATE软件,建立了人体腹部放疗仿真模型;仿真计算了 259.5 AMeV碳离子脉冲进入放疗模体后发生核碎裂和熔合-削去反应产生的正电子核素规律,结果显示1 s间歇时间内11C、10C、15O三种核素产额占比达到85%,验证了碳离子放疗过程中采用在束正电子断层成像技术(In-beam PET)测量的有效性;仿真分析了 200、215、230 AMeV三种能量碳离子束在放疗模体靶体内衰变产生的正电子核素活度峰和剂量峰位置分布规律,建立了活度曲线峰值位置和剂量曲线峰值位置关系数学模型,从而实现了利用在束正电子断层成像技术(In-beam PET)测量靶体内的活度分布来准确监测剂量峰值位置.
Monte Carlo simulation of carbon ion radiotherapy module radiation field based on GATE
Basedon GAT Esoftware,a simulation model of human abdominal radiotherapy was estab-lished.The simulation calculated the nuclide law of positron nuclide generated by nuclear fragmentation and fusion-shaving reaction after the 215 AMeV carbon ion pulse entered the radiotherapy mold,and the results showed that the yield of 11C,10C and 150 accounted for 97%of the three nuclides in one second interval,which verified the effectiveness of the measurement in beam positron tomography(In-beam PET)during carbon ion radiotherapy.The distribution of positron nuclide activity peaks and dose peak positions generated by the decay of 200 AMeV,215 AMeV and 230 AMeV energy carbon ion beams in theradiotherapy model target was simulated and analyzed,and a mathematical model of the relationship between the peak position of the activity curve and the peak position of the dose curve was established,so as to accurately monitor the peak position of the dose by measuring the activity distribution in the target by In-beam PET.

carbon ion radiotherapyhuman abdominal modelmonte carlo simulationpositron nu-clide activitydose distribution

张育生、张卫星、郝秋实、张文伟、逄文华

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莱阳市检验检测中心,山东烟台 265200

烟台市标准计量检验检测中心,山东烟台 264003

碳离子放疗 人体腹部模型 蒙特卡罗模拟 正电子核素活度 剂量分布

2024

工业计量
冶金自动化研究设计院 中国计量协会

工业计量

影响因子:0.256
ISSN:1002-1183
年,卷(期):2024.34(3)
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