基于GATE的碳离子放疗模体辐射场蒙特卡洛仿真研究
Monte Carlo simulation of carbon ion radiotherapy module radiation field based on GATE
张育生 1张卫星 1郝秋实 2张文伟 2逄文华2
作者信息
- 1. 莱阳市检验检测中心,山东烟台 265200
- 2. 烟台市标准计量检验检测中心,山东烟台 264003
- 折叠
摘要
基于GATE软件,建立了人体腹部放疗仿真模型;仿真计算了 259.5 AMeV碳离子脉冲进入放疗模体后发生核碎裂和熔合-削去反应产生的正电子核素规律,结果显示1 s间歇时间内11C、10C、15O三种核素产额占比达到85％,验证了碳离子放疗过程中采用在束正电子断层成像技术(In-beam PET)测量的有效性;仿真分析了 200、215、230 AMeV三种能量碳离子束在放疗模体靶体内衰变产生的正电子核素活度峰和剂量峰位置分布规律,建立了活度曲线峰值位置和剂量曲线峰值位置关系数学模型,从而实现了利用在束正电子断层成像技术(In-beam PET)测量靶体内的活度分布来准确监测剂量峰值位置.
Abstract
Basedon GAT Esoftware,a simulation model of human abdominal radiotherapy was estab-lished.The simulation calculated the nuclide law of positron nuclide generated by nuclear fragmentation and fusion-shaving reaction after the 215 AMeV carbon ion pulse entered the radiotherapy mold,and the results showed that the yield of 11C,10C and 150 accounted for 97％of the three nuclides in one second interval,which verified the effectiveness of the measurement in beam positron tomography(In-beam PET)during carbon ion radiotherapy.The distribution of positron nuclide activity peaks and dose peak positions generated by the decay of 200 AMeV,215 AMeV and 230 AMeV energy carbon ion beams in theradiotherapy model target was simulated and analyzed,and a mathematical model of the relationship between the peak position of the activity curve and the peak position of the dose curve was established,so as to accurately monitor the peak position of the dose by measuring the activity distribution in the target by In-beam PET.
关键词
碳离子放疗/人体腹部模型/蒙特卡罗模拟/正电子核素活度/剂量分布Key words
carbon ion radiotherapy/human abdominal model/monte carlo simulation/positron nu-clide activity/dose distribution引用本文复制引用
出版年
2024
NETL
NSTL
万方数据