Objective To investigate the value of systemic immune-inflammation index(SII)in evaluating the prognosis of elderly patients with diffuse large B-cell lymphoma(DLBCL).Methods Ninety-one elderly patients(≥60 years old)diagnosed with DLBCL were selected as study subjects.Relevant information was collected,including age,gender,smoking status,clinical stage,American Eastern Cooperative Oncology Group(ECOG)score,international prognostic index(IPI)and the number of extra-nodal involvement were collected.Fasting blood samples were obtained from the patients to measure serum platelet count(PLT),neutrophil(NE)count,and lymphocyte(LYM)count using Coulter principle.SII was calculated based on PLT,NE,and LYM values.Lactate dehydrogenase(LDH)level was measured using immunological assays,while β2-microglobulin(β2-MG)level was determined using immunoturbidimetry assay.The optimal cutoff value for SII was determined using receiver operating characteristic(ROC)curve analysis,used for stratifying the patients into high-and low-SII groups.Differences in clinical characteristics between two groups were analyzed using both univariate and multivariate approaches.Two groups of patients were followed up for their survival status.The 3-year overall survival(OS)rate and progression-free survival(PFS)rate were calculated.R-studio was applied to construct a prognosis prediction model for elderly DLBCL patients with SII as the main focus.Results ROC curve results showed that the critical value of SII was 582.6.The elderly patients with DLBCL were divided into a high-SII group(SII≥582.6,n=57)and a low-SII group(SII＜582.6,n=34).The area under the curve(AUC)of the ROC in both groups was0.651,with a95％ CI of 0.535-0.766(P=0.015).Survival curves shows that OS and PFS of elderly patients with DLBCL in low-SII group were higher than those in high-SII group.High SII was an independent prognostic factor affecting OS and PFS of elderly patients with DLBCL(P＜0.05).The prognosis prediction model based on SII in elderly patients with DLBCL was statistically significant(P＜0.05).Conclusion SII level is correlated with the prognosis of the elderly patients with DLBCL,and the prognosis of high-SII group is worse.
关键词
危险因素/预后/列线图/弥漫大B细胞淋巴瘤/全身免疫炎症指数/老年患者
Key words
risk factors/prognosis/nomogram/diffuse large B-cell lymphoma/systemic immune-inflammation index/elderly patients
维普
万方数据