Objective To investigate the clinical efficacy of varied glucocorticoid administration in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods Eighty-eight AECOPD patients were randomized into inhalation and venous groups on even number.On the basic treatment of anti-infection,oxygen inhalation,expectorant,anti-spasmodic and anti-asthma,and diastolic airway,patients in the venous group received intravenous methylprednisolone sodium succinate(40 mg/time,1 time/d),while patients in the inhalation group inhaled budesonide(2 mg/time,3 times/d).Both groups were treated for 7 d.Comparing the results of both groups:arterial oxygen partial pressure(PaO2),arterial carbon dioxide partial pressure(PaCO2),the estimated ratio of forced expiratory volume in the first second(FEV1％),the ratio of forced expiratory volume in the first second(FEV1/FVC),self-assessment test(CAT).Results Compared with pretreatment,PaO2 increased,PaCO2 decreased,FEV1％and FEV1/FVC were elevated in both groups(P＜0.05);CAT scores decreased in both groups(P＜0.05);treatment efficacy was comparable between both groups,but the incidence of adverse effects in the inhalation group was lower than that of venous group(P＜0.05).Conclusion Glucocorticoid treatment of AECOPD patients can achieve positive clinical efficacy regardless of the method of administration,but glucocorticoid inhalation shows fewer adverse reactions and higher safety than intravenous glucocorticoid application.
关键词
慢性阻塞性肺疾病/急性加重期/糖皮质激素/不同给药方式/肺功能/血气分析
Key words
chronic obstructive pulmonary disease/acute exacerbation/glucocorticoid/varied administration/pulmonary function/blood gas analysis
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