Objective The expression of platelet(PLT)antibody in the serum of pregnant women was detected and the related influencing factors of PLT antibody positive in this population were analyzed.Methods A total of 2,790 pregnant women were selected as the study subjects,and PLT antibody screening was performed by solid phase erythrocyte agglutination method.Platelet anti-human leukocyte antigen(HLA)and anti-human platelet antigen(HPA)were further detected among the antibody-positive women,and they were grouped according to blood transfusion history,previous pregnancy history,ethnicity,and gestational age respectively to evaluate the effect of PLT antibody positive in pregnant women.Results Among 2,790 pregnant women,367 cases(positive rate 13.15％)of PLT antibodies were detected,among which anti-HLA,anti-HPA and anti-HLA+anti-HPA accounted for 47.96％,39.24％,and 12.80％,respectively;the total positive rate of PLT antibody was compared between groups with or without blood transfusion history,and the difference was statistically significant(P＜0.05).There was statistical significance(P＜0.05)in the total positive rate of PLT antibody between groups with or without previous pregnancy history;there was no significant difference(P＞0.05)in the total positive rate of PLT antibody between Han and minority groups.Grouping by gestational age,it was found that as gestational age increased,the positivity rate of anti HLA increased(P＜0.05),and 9 pregnant women with negative PLT antibodies in early pregnancy and positive PLT antibodies in late pregnancy were also found.The history of blood transfusion and previous pregnancy are risk factors for its occurrence.Conclusion The positive typing results of PLT antibodies in pregnant women are mainly anti-HLA,and the production of PLT blood group antibodies is closely related to the history of pregnancy and blood transfusion.According to the history of blood transfusion and pregnancy history,the dynamic monitoring of PLT antibodies in pregnant women can be more effective.
platelet antibody detectionanti-HLAanti-HPApregnant womennationhistory of blood transfusionhistory of pregnancygestational age
维普
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