Objective To investigate the association between serum vitamin D levels and lipid profiles in early pregnancy.Methods A total of 257 pregnant women was enrolled for this study.Data on age,educational background,and other demographic information were collected through direct interviews.Heights were measured using a stadiometer,while pre-pregnancy weight was self-reported,allowing for the calculation of pre-pregnancy BMI.Measurements of fundal height and abdominal circumference were taken with a tape measure.Fasting venous blood samples(5 mL)were collected in the morning to assess serum vitamin D levels,using the Roche Cobas c702 analyzer for total cholesterol(TC),triglycerides(TG),HDL-C,and LDL-C levels.Logistic regression analysis was applied to examine the correlation between serum VD and lipid indicators.Results The median serum vitamin D level among the participants was 43.25(28.88,58.63)nmol/L,with a deficiency rate of 59.53％.The study identified statistically significant variations in TG and HDL-C across different vitamin D level groups(P＜0.05),indicating a trend of increase corresponding with higher vitamin D levels.After adjusting for confounders such as age,pre-pregnancy BMI,and abdominal circumference,serum vitamin D levels were found to be a significant predictor of lipid profile abnormalities,with an OR(95％CI)of 1.037(1.003,1.071),P=0.031.Conclusion Vitamin D deficiency is prevalent among early-stage pregnant women,suggesting a potential link between serum vitamin D levels and lipid profile abnormalities.
关键词
妊娠早期/血清维生素D/血脂/血脂异常/脂代谢
Key words
early pregnancy/serum vitamin D/blood lipids/dyslipidemia/lipid metabolism
维普
万方数据