Objective To investigate the relationship between nocturnal apnea events and cognitive impairment in elderly patients with obstructive sleep apnea hypopnea syndrome(OSAHS).Methods A total of 85 elderly OSAHS patients were selected as the normal group(n=52)and obstructive group(n=33)based on the Montreal Cognitive Assessment(MoCA)scores.Cognitive function characteristics between the two groups were compared.Multichannel sleep monitoring was used to record following data of both groups:the apnea-hypopnea index(AHI),respiratory disturbance index(RDI),sleep efficiency(SE),lowest oxygen saturation(LSPO2),mean oxygen saturation(MaSO2),as well as the number of nocturnal apnea events,average duration of apnea events,and the longest duration of apnea events.Levels of insulin-like growth factor 1(IGF-1),monocyte chemoattractant protein-1(MCP-1),and Caspase-3 were also measured before treatment.Pearson was adopted to analyze correlation between nocturnal apnea condition and serum index,as well as the correlation between nocturnal apnea events and cognitive impairment.Multiple linear regression model was adopted to analyze the risk factors of cognitive impairment in patients.Results The obstructive group showed significantly lower scores than normal group in visuospatial and executive functions,naming,attention,language,abstraction,delayed memory,and orientation(P＜0.05).Obstructive group showed higher record than normal group in terms of age,disease duration,number of apnea events,average duration of apnea events,longest duration of apnea events,AHI,RDI,MCP-1,and Caspase-3 levels,while SE,LSPO2,MaSO2,and IGF-1 of obstructive group were significantly lower than normal group(P＜0.05).Number of nocturnal apnea and duration were negatively correlated with IGF-1,but positively correlated with MCP-1 and Caspase-3 levels(P＜0.05).MoCA scores of patients were negatively correlated with age,disease duration,AH,IRI,number of apnea events,average duration of apnea events,longest duration of apnea events,MCP-1,and Caspase-3 levels,while the scores were positively correlated with SE,LSPO2,MaSO2,and IGF-1 levels(P＜0.05).Multivariate linear regression analysis revealed number of apnea events,average duration of apnea events,longest duration of apnea events were risk factors of cognitive impairment for patients(P＜0.05).Conclusion The number and duration of nocturnal apnea events in elderly OSAHS patients are positively correlated with the degree of cognitive impairment.Apnea events increase the risk of cognitive impairment in patients.
维普
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