Distribution patterns and drug resistance characteristics of pathogenic bacteria in inpatients with Alzheimer's disease complicated with deep infection
Distribution patterns and drug resistance characteristics of pathogenic bacteria in inpatients with Alzheimer's disease complicated with deep infection
Objective To investigate the distribution patterns and drug resistance characteristic of pathogenic bacteria in inpatients with Alzheimer's disease(AD)complicated with deep infection.Methods A total of 350 patients with AD complicated with deep infection were selected as research subjects.A total of 350 samples were collected,including sputum(n=244),urine(n=83),blood(n=20),and other secretion(n=3)specimens from the patients to isolate and culture pure bacterial colonies.Automated microbial identification system was applied to identify bacteria species in pure colonies.Sputum samples were collected from 164 patients who had typical AD clinical signs and pulmonary infection,then isolated,cultured for obtaining pure colonies.The bacterial species in pure colonies were identified using automated microbial identification system.Statistics was performed on the underlying diseases and death status of the 164 patients.A total of 155 major strains which ranked the top 5 from the patients with AD complicated with pulmonary infections were selected for drug sensitivity testing,and their pulmonary imaging data were collected.Results A total of 397 strains of pathogenic bacteria were cultured from 350 samples of the patients with AD complicated with deep infection.The most abundant bacterium was Pseudomonas aeruginosa(23.93％),and the most abundant fungus was Candida albicans(5.04％).The patients with AD complicated by pulmonary infection often had multiple underlying diseases.Patients with diabetes accounted for the first place(53.66％),followed by the patients with hypertension(47.56％).Drug sensitivity test results showed that Acinetobacter baumannii had the highest resistance rate to piperacillin/tazobactam(47.36％),and Escherichia coli had the highest resistance rate to ciprofloxacin(44.44％).P.aeruginosa had the highest resistance rate to gentamicin(59.25％),and Staphylococcus aureus had the highest resistance rate to cephalosporin(70.58％).Klebsiella pneumoniae had the highest resistance rate to cefepime(38.29％).The common imaging manifestations of the patients with AD complicated with pulmonary infection were mainly lobular pneumonia,while interstitial pneumonia and pulmonary abscess were rare.Conclusion The majority of pathogenic bacteria in patients with AD complicated with deep infections are gram-negative bacteria,and the most common site of infection is in the lung.These strains have a high resistance rate to ciprofloxacin,levofloxacin,ceftazidime,cefepime,and gentamicin.
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