Effect of ultra-minimally invasive needle knife endoscopy-guided peripheral nerve coblation on inflammatory factors and matrix metalloproteinases in synovial fluid of patients with early knee osteoarthritis
Effect of ultra-minimally invasive needle knife endoscopy-guided peripheral nerve coblation on inflammatory factors and matrix metalloproteinases in synovial fluid of patients with early knee osteoarthritis
Objective To investigate the clinical efficacy and mode of action of ultra-minimally invasive needle knife endoscopy-guided peripheral nerve coblation in treating patients with early knee osteoarthritis(KOA).Methods A total of 90 patients with early stage KOA were divided into experimental group,control group A and control group B(30 cases/group).Control group A was given with oral celecoxib and glucosamine sulfate capsules,control group B with medial ozone knee perfusion combined with drug therapy and experimental group with ultra minimally invasive needle knife endoscopy-guided peripheral nerve coblation combined with drug therapy.Pain degree,joint function,inflammatory factors,matrix metalloproteinases and adverse reactions in synovial fluid were compared among three groups before treatment,one month after treatment and six months after treatment.Results After 6 months of treatment,Visual Analog Scale(VAS)was lower in experimental group than those in control groups A and B(P＜0.05).Western Ontario and McMaster Universities Osteoarthritis index(WOMAC)was lower in experimental group than those in control groups A and B at 1 and 6 months after treatment(P＜0.05).The levels of interleukin-1(IL-1),IL-6,and tumor necrosis factor-α(TNF-α)in synovial fluid were lower in experimental group than those in control groups A and B(P＜0.05).The levels of matrix metalloproteinase-2(MMP-2),MMP-3,and MMP-9 in synovial fluid were lower in experimental group than those in control groups A and B(P＜0.05),while the levels of matrix metalloproteinase-2(MMP-2),MMP-3,and MMP-9 in synovial fluid were lower in experimental group than those in control groups A and B(P＜0.05).Conclusion The combination of minimally invasive needle knife endoscopy-guided coblation and drug therapy can alleviate pain symptoms in the patients with early KOA,improve knee joint function.It might be related to inhibiting inflammatory mediator infiltration in synovial fluid and promoting the growth of chondrocytes and tissues.
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