Objective To investigate value of peripheral blood lymphocyte-monocyte ratio(LMR)to lactate dehydrogenase(LDH)ratio(LMR/LDH)in the prognosis of patients with diffuse large B-cell lymphoma(DLBCL)complicated with hepatitis B virus.Methods The following clinical data of 77 patients with DLBCL combined with hepatitis B virus infection were collected:gender,age,clinical stage,B symptoms,Eastern Cooperative Oncology Group(ECOG)score,number of extranodal involvement,international prognostic index(IPI)score.Fasting anticoagulated whole blood and venous blood were collected before treatment.The combined detection method of electrical impedance,high-frequency conductivity,and laser scattering were used to measure the absolute values of lymphocytes and monocytes,and LMR was calculated.Ultraviolet spectrophotometry was utilized to detect serum LDH and immunoturbidimetry was used to detect β2-microglobulin(β2-MG).All patients were followed up for 36 months after discharge,and the overall survival(OS)and progression-free survival(PFS)were recorded.The critical value of LMR/LDH was determined by Receiver Operating Characteristic(ROC)curve,and the effect of LMR/LDH on OS and PFS was analyzed.COX regression model was used to analyze the relationship between LMR/LDH and clinical characteristics of patients.Results ROC curve analysis showed that the critical value of LMR/LDH was 0.008,the sensitivity and specificity were 0.660 7 and 0.761 9,respectively.The area under the curve(AUC)was 0.705 4(95％CI was from 0.549 1 to 0.893 7,P=0.005 7).LMR/LDH was significantly correlated with clinical stage,ECOG score,number of extranodal involvement,IPI,LDH and β2-MG(P＜0.05).Univariate analysis showed that LMR/LDH,clinical stage,and ECOG ≥2,number of extranodal involvement≥2,IPI,LDH,β2-MG had significant effects on OS and PFS of patients(P＜0.05).Multivariate analysis showed that LMR/LDH was an independent risk factor affecting OS and PFS in DLBCL patients with hepatitis B virus(P＜0.05).The high LMR/LDH group exhibited improved OS and PFS compared to the low LMR/LDH group.Conclusion LMR/LDH has certain clinical predictive value for the prognosis of patients with DLBCL complicated with hepatitis B virus.
lymphoma,B-cell/lactate dehydrogenases/lymphocyte to monocyte ratio/diffuse large B-cell lymphoma/hepatitis B virus/overall survival/relapse-free survival
维普
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