Objective To explore the clinical value of non-invasive model in evaluating the degree of hepatic fibrosis in chronic hepatitis B.Methods The data of 92 patients with chronic hepatitis B diagnosed as hepatic fibrosis by liver puncture biopsy were collected.According to the degree of hepatic fibrosis,the patients were divided into mild hepatic fibrosis and significant hepatic fibrosis groups.Automatic biochemical analyzer was used to detect aspartate aminotransferase(AST)and alanine aminotransferase(ALT)in venous blood of the patients.Blood cell analyzer was used to measure platelet(PLT)count and red blood cell distribution width(RDW)in venous blood of the patients.AST/ALT ratio(AAR),AST/PLT ratio(APRI),RDW/PLT ratio(RPR)and fibrosis index based on the 4 factors(F I B-4)were calculated.Area under receiver operating characteristic(ROC)curve(AUC)was used to evaluate the diagnostic value of the above non-invasive model for hepatic fibrosis.Results Serum ALT,AST,APRI,RPR,and FIB-4 were lower in mild hepatic fibrosis group than those in significant hepatic fibrosis group(P＜0.05),while PLT and AAR were higher than those in significant hepatic fibrosis group(P＜0.05).The AUCs of AAR,APRI,PPR,and FIB-4 for evaluating the degree of hepatic fibrosis in chronic hepatitis B were 0.406,0.711,0.729,and 0.692,respectively.The AUC for the combined four indicators was 0.741,which was significantly higher than any individual indicator alone(P＜0.05).Conclusion APRI,RPR,and FI B-4 are effective indicators for diagnosing the degree of hepatic fibrosis in patients with chronic hepatitis B.Combined application of the four models can improve the accuracy of diagnosis and prediction of the fibrosis in hepatitis B.
维普
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