Objective To explore clinical value of inflammatory indexes in early evaluating refractory mycoplasma neumonia(RMPP)in children.Methods A total of 1000 children with mycoplasma pneumoniae pneumonia(MPP)were included in the study and divided into conventional MPP group(n=762)and RMPP group(n=238)based on their severity.Inflammatory response indexes[C-reactive protein(CRP),neutrophils,procalcitonin(PCT),serum amyloid A(SAA),erythrocyte sedimentation rate(ESR),alanine aminotransferase(ALT),lactate dehydrogenase(LDH),α-Hydroxybutyrate dehydrogenase(HBDH),D-dimer(D-D),and ferritin]on the first day after admission were compared between two groups.RMPP patients were divided into effective and ineffective groups based on treatment efficacy.Inflammatory response indexes and their correlation with therapeutic efficacy were compared among RMPP patients with different therapeutic effects before and after treatment(on the first day after admission,at one week after treatment).ROC curvea of inflammatory response indexes were used to analyze the value of diagnosing RMPP.Results CRP,neutrophils,PCT,SAA,ESR,ALT,LDH,HBDH,D-D,and ferritin were higher in RMPP group than those in MPP group(P＜0.05).After treatment,RMPP group had 48 children showing significant improvement and 152 children showing effective improvement,and the total number of children showing effective was 200,accounting for 84.03％,with 38 children ineffective,accounting for 15.97％.When compared with before treatment,CRP,neutrophils,PCT,SAA,ESR,ALT,LDH,HBDH,D-D,and ferritin in RMPP group were decreased after treatment(P＜0.05),and they were lower in effective group than those in ineffective group(P＜0.05).Person correlation analysis showed that CRP,neutrophils,PCT,SAA,ESR,ALT,LDH,HBDH,D-D,and ferritin were negatively correlated with therapeutic efficacy(P＜0.05).ROC curve analysis revealed that these indexes had certain values in diagnosing RMPP.Conclusion Inflammation indexes based on inflammatory response exhibit good values in early diagnosing RMPP in children.
refractory mycoplasma pneumoniachildrenearly assessmentinflammatory response indexclinical value
维普
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