Objective To analyze the association of serum carcinoembryonic antigen-related cell adhesion molecule-1(CEACAM1),bone marker sclerotin(SOST),procollagen type Ⅰ amino-terminal peptide(P1NP)and bone mineral density(BMD)in patients with breast cancer as well as the predictive value for osteoporosis.Methods Retrospective study was conducted on 52 patients with breast cancer,who were selected as breast cancer group.Additionally,50 patients with benign hyperplasia of the breast who were admitted to the department of breast at our hospital during the same period were selected as benign hyperplasia of the breast group,and 53 patients with simple menopause at the physical examination center of our hospital during the same period were selected as control group.All patients with breast cancer were measured by dual energy X-ray bone densitometer at admission.According to BMD,the patients were divided into osteoporosis group(n=10),low BMD group(n=36)and normal BMD group(n=6).Immunoluminescence was used to detect serum CEACAM1 and P1NP levels in research subjects.Enzyme linked immunosorbent assay(ELISA)was applied to detect SOST level.The levels of serum CEACAM1,SOST,P1NP,and lumbar spine BMD in the patients with breast cancer were compared before and after chemotherapy.Serum CEACAM1,SOST,and P1NP levels of the patients with breast cancer were compared among different BMD groups.Pearson correlation was conducted to analyze the association of serum levels of CEACAM1,SOST,and P1NP with lumbar spine BMD.ROC curve was used to analyze the predictive values of serum CEACAM1,SOST,and P1NP levels for osteoporosis.Results Serum CEACAM1 level and lumbar spine BMD before and after chemotherapy were lower in breast cancer group than those in benign hyperplasia of the breast and control groups,while the levels of SOST and P1NP were higher than those in benign hyperplasia of the breast and control groups(P＜0.05).Serum CEACAM1 level and lumbar spine BMD of patients with breast cancer were lower after chemotherapy than those before chemotherapy(P＜0.05),while serum SOST and P1NP levels were higher than those before chemotherapy(P＜0.05).Serum CEACAM1 level was lower in osteoporosis group than that in low BMD and normal BMD groups(P＜0.05),while serum SOST and P1NP levels were higher than those in low BMD and normal BMD groups(P＜0.05).Serum CEACAM1 level was positively correlated with lumbar spine BMD(r=0.405,P＜0.05),while serum SOST and P1NP levels were negatively correlated with lumbar spine BMD(r=-0.399,-0.412;P＜0.05).AUC of the combined detection of serum CEACAM1,SOST,and P1NP levels in predicting osteoporosis was 0.799(95％CI was 0.721-0.957),with higher sensitivity and specificity than those of single detection(P＜0.05).Conclusion Serum CEACAM1,SOST and P1NP levels in patients with breast cancer are correlated with bone mineral density.The combined detection of serum CEACAM1,SOST,P1NP levels can improve the sensitivity and specificity of predicting osteoporosis.
关键词
乳腺肿瘤/癌胚抗原相关细胞黏附分子1/骨标志物硬化蛋白/Ⅰ型前胶原氨基端延长肽/骨密度
Key words
breast cancer/carcinoembryonic antigen-related cell adhesion molecule 1/bone marker sclerosin/type Ⅰ procollagen amino-terminal peptide/bone mineral density
维普
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