摘要
目的 探讨萆苓汤用于急性期痛风性关节炎、中医辨证属湿热蕴结证患者的治疗效果.方法 86例急性发作期痛风性关节炎、中医辨证属湿热蕴结证的患者随机均分为对照组(n=43,依托考昔治疗)和观察组(n=43,对照组方案上加服萆苓汤),治疗14 d;采用中医证候积分法评价2组患者治疗前后症状的严重程度;于治疗前及治疗后,采用流式细胞仪检测血清肿瘤坏死因子(TNF-α)、白细胞介素-6(IL-6)、IL-8及IL-1β,全自动生化分析仪和特种蛋白分析仪检测血清尿酸(UA)和C反应蛋白(CRP),检测红细胞沉降率(ESR),记录2组患者出现的药物不良反应,评价临床疗效.结果 2组患者治疗前的一般临床资料、中医证候积分及血清CRP、ESR、UA、TNF-α、IL-1 β、IL-8、IL-6比较,差异均无统计学意义(P＞0.05);2组患者治疗后中医证候积分及血清CRP、ESR、UA、TNF-α、IL-1 β、IL-8、IL-6指标均较治疗前明显下降(P＜0.001),且观察组低于对照组(P＜0.05);2组患者不良反应发生率比较,差异无统计学意义(P＞0.05);观察组患者有效率高于对照组(P＜0.05).结论 萆苓汤对急性期痛风性关节炎湿热蕴结证患者的治疗有效、安全性高、毒副作用小.
Abstract
Objective To explore the therapeutic effect of Bi-Ling Tang in patients with acute gouty arthritis and TCM syndrome differentiation.Methods A total of 86 patients with acute gouty arthritis and TCM syndrome differentiation were randomly divided into control group(n=43,Etoricoxib treatment)and observation group(n=43,treatment with Etoricoxib plus Bi-Ling Tang)for 14 days.The severity of symptoms in patients of two groups before and after treatment was evaluated by the traditional Chinese medicine syndrome integral method.Before and after treatment,serum tumor necrosis factor(TNF-α),interleukin-6(IL-6),IL-8,and IL-1β were measured by flow cytometry.Serum uric acid(UA)and C reactive protein(CRP)were detected by automatic biochemical analyzer and special protein analyzer,erythrocyte sedimentation rate(ESR)was determined,adverse drug reactions in group 2 were recorded,and clinical efficacy was evaluated.Results The general clinical data in two groups of patients before treatment,TCM syndrome points,and serum CRP,ESR,UA,TNF-α,1L-1β,IL-8,and IL-6 were compared,and the differences were statistically significant(P＞0.05).In group 2,TCM syndrome score and serum CRP,ESR,UA,TNF-α,IL-1 β,IL-8,IL-8,and IL-6 indexes were all significantly decreased compared with those before treatment(P＜0.001),and the observation group were lower than the control group(P＜0.05).The incidence of adverse reactions in two groups of patients was compared,and there was no statistically significant difference(P＞0.05).Patients in the observation group had a higher effective rate than those in the control group(P＜0.05).Conclusion Bi-Ling Tang is effective,with high safety and little side effects for patients with acute gouty arthritis.
基金项目
北京市中医药科技发展资金项目(QN-2020-08)
NETL
NSTL
万方数据