Effect of hyperbaric oxygen therapy at different stages on sleep disorders after acute cerebral infarction analyzed by polysomnography
Objective To investigate the effect of hyperbaric oxygen therapy(HBOT)at different stages on sleep disorders after acute cerebral infarction analyzed by polysomnography.Methods A total of 120 patients with sleep disorders after acute cerebral infarction were randomly divided into observation and control groups.All patients were treated with oral flupentixol and melitracen tablets.Observation group was treated with hyperbaric oxygen at 0-7 days after onset,and control group was treated with hyperbaric oxygen at 8-14 days after onset.Polysomnography was used to detect total sleep time(TST),sleep efficiency(SE),the first stage of sleep(TS1),the second stage of sleep(TS2),the third stage of sleep(TS3),the fourth stage of sleep(TS4),rapid eye movement sleep time(REM),wake after sleep onset(WASO)and sleep latency time(SL)to assess the patients'sleep status before treatment and at 4 weeks after treatment.The patients'sleep latency,TST and the times of awakenings were recorded to evaluate therapeutic effect.Fasting venous blood was collected to detect cholinesterase activity.Hamilton Depression Scale(HAMD)was used to evaluate the negative emotions of patients.Adverse sleep events were recorded.Results After treatment,TST,SE,TS1,TS2,TS3,TS4,REM,WASO,and SL in two groups were significantly improved,and they were better in observation group than in control group(P＜0.05).After 4 weeks of treatment,SL,TST and the times of awakenings of two groups were improved when compared to before treatment,and SL and the times of awakenings were lower in observation group than those in control group,while TST was higher observation group than that of control group(P＜0.05).After treatment,blood cholinesterase activity was significantly lower in observation group than that in control group(t=30.233,P＜0.001).After treatment,HAMD was decreased in two groups.HAMD was obviously lower in observation group than that in control group(P＜0.05).After treatment,periodic limb movements and abnormal rapid eye movement sleep behavior during sleep were lower in observation group than those in control group had(P＜0.05).Conclusion Early administration of HBOT is effective for patients with sleep disorders after acute cerebral infarction,and polysomnography may monitor the therapeutic effect of HBOT.
polysomnographyhyperbaric oxygenacute cerebral infarctionsleep disordersimprovement of sleep function
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