Risk factors of left ventricular hypertrophy in children with chronic kidney diseases
Objective To investigate the clinical features and risk factors for combined left ventricular hypertrophy(LVH)in children with chronic kidney disease(CKD).Methods The clinical data such as age,gender,etiology,onset of symptoms,laboratory indices,auxiliary examination,and treatment of 549 children with CKD,and their general conditions,etiological composition,complications,and treatment were collected and analyzed.The children were grouped according to whether they had combined LVH or not,and the age,sex,disease duration,body mass index(BMI),hemoglobin,blood phosphorus,blood calcium,bicarbonate(HCO3-)level,and CKD stage were compared between the two groups,and the factors with statistically significant differences were included in the single-factor and multi-factor logistic regression models to screen out the risk factors for combined LVH in children with CKD.Results Among the children with CKD of all ages,the incidence rate was the highest in the age group of 6-≤12 years old,followed by children in the age group of＜3 years old,and congenital kidney and urinary tract malformations(CAKUT)accounted for the highest proportion of the causes of CKD in children aged＜3 years(P＜0.01).Compared with children with CKD stage 1,CKD stages 2-5 had a higher proportion of CAKUT in the etiology(P＜0.01)and the highest proportion in asymptomatic onset(95.19％).The incidences of low body weight,hypertension,anemia and hyperphosphatemia in CKD stage 5 were higher than those in CKD stages 2-4(P＜0.05).There were statistically significant differences in Hb,serum phosphorus,serum HCO3-levels and CKD stage among LVH and non-LVH CKD patients(P＜0.05).Multivariate logistic regression analysis showed that H b ≤ 90 g/L,CKD stages 2-5,and hypertension were risk factors for LVH in children with CKD(OR=2.564,19.116,31.041;P＜0.05).Conclusion The primary cause of CKD in children under 3 years old is mainly CAKUT.Factors such as Hb≤90 g/L,stage of CKD,and hypertension are risk factors for LVH in children with CKD.
万方数据
维普
